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METHADOSE is contraindicated in individuals with acknowledged or suspected gastrointestinal obstruction, which includes paralytic ileus. The methadone in METHADOSE might induce spasm of the sphincter of Oddi.​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​â